اثرات محافظتی عصاره گل گیاه ازگیل ژاپنی بر سطوح MANF ساقه مغز در برابر سم 6- هیدروکسی دوپامین در رت

  Background : Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson’s disease (PD). Eriobotrya Japonica flower extract (EJFE) has abundant amount of phenolic compounds. This study was performed with the aim of protective effects of Eriobotrya Japonica flower extract on intraventricular 6-hydroxydopamine-induced lesion in male rats .   Methods: In this laboratory experimental study rats were divided into three groups: basic, Control and extract-Parkinson. At the final study stage, the control and extract-parkinson groups received 6-hydroxydopamine (6-OHDA) (dissolved in saline) and experienced the stress. The extract-Parkinson group received 200 mg/kg EJFE intraperitoneally three times per week for 12 weeks. The Mesencephalic Astrocyte-derived Neurotrophic Factor ( MANF) levels in the brainstem were measured by ELISA method.   Results : Data was analyzed using one-way analysis of variance (ANOVA) and Tukey post-hoc test. Results showed that the EJFE significantly decrease the MANF levels in Parkinson rats (p=0.042).   Conclusion: The results of this study showed that pre-treatment with hydroalcoholic extraction of Eriobotrya japonica increases protection against 6-OHDA lesion and may have protective role against Parkinson disease.